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主要研究方向:肝炎、肝纤维化靶向诊断和治疗研究。
目前主要聚焦于代谢组学领域的研究。在代谢组学这一前沿科学中,致力于探索生物体内代谢物的变化规律及其与生理、病理过程的关联。通过运用高效液相色谱、质谱等先进技术,精准分析和鉴定复杂生物样本中的代谢物,揭示疾病机制、寻找生物标志物以及药物作用新靶点。
研究成果:
1. Multi-omics analysis provides new insights into mechanism of didymin on non-alcoholic fatty liver disease in rats. Phytomedicine 135 (2024) 156016.
2. The Regulatory Mechanism of Smilax China L. Saponins against Nonalcoholic Fatty Liver Is Revealed by Metabolomics and Transcriptomics. J. Oleo Sci. 73, (5) 695-708 (2024).
3. Integrative Analysis of Transcriptome and Metabolome to Illuminate the Protective Effects of Didymin against Acute Hepatic Injury. Mediators of Inflammation, Volume 2023, Article ID 6051946
4. Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics. Front. Pharmacol. 13:801982.
5. Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics. Drug Design, Development and Therapy. 2022:16 1713–1729
6. Comprehensive analysis of transcriptomics and metabolomics to illustrate the underlying mechanism of helenalin against hepatic fibrosis. European Journal of Pharmacology 919 (2022) 174770
7. Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K/Akt and NF-κB pathways. International Immunopharmacology 92 (2021) 107208.
8. Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice. International Immunopharmacology 88 (2020) 107003
9. Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy. Biomedicine & Pharmacotherapy 129 (2020) 110375
10. 4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice. International Immunopharmacology 83 (2020) 106445
11. 4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways. Am J Transl Res 2020;12(5):2169-2180
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